The decline in use of β-carotene and vitamin E supplements followed reports of adverse outcomes in lung cancer and all-cause mortality, respectively.In contrast, sales of multivitamins and other supplements have not been affected by major studies with null results, and the U. supplement industry continues to grow, reaching billion in annual sales in 2010.
The decline in use of β-carotene and vitamin E supplements followed reports of adverse outcomes in lung cancer and all-cause mortality, respectively.In contrast, sales of multivitamins and other supplements have not been affected by major studies with null results, and the U. supplement industry continues to grow, reaching billion in annual sales in 2010.This evidence, combined with biological considerations, suggests that any effect, either beneficial or harmful, is probably small.
After a median follow-up of 4.6 years, there was no significant difference in recurrent cardiovascular events with multivitamins compared with placebo (hazard ratio, 0.89 [95% CI, 0.75 to 1.07]).
The trial was limited by high rates of nonadherence and dropouts.
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Evidence is sufficient to advise against routine supplementation, and we should translate null and negative findings into action.